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Perls Prussian Blue
Prussian blue is a common stain used by pathologists to detect the presence of iron in biopsy specimens, such as deposits of storage ferritin in bone marrow biopsy samples.
Hematoxylin and Eosin
For routine examination, haematoxylin and eosin (H&E) is the stain of choice. This stain produces colours different tissue structures, which would otherwise be transparent, so that you can get a detailed view of the tissue.
Vimentin
This antibody is intended for use to qualitatively identify vimentin by light microscopy in sections of formalin fixed, paraffin embedded tissue. The clinical interpretation of any staining, or the absence of staining, must be complemented by...
Masson's Trichrome
This stain is used to differentiate between collagen and smooth muscle in tumors, and the increase of collagen in diseases such as cirrhosis. Routine stain for liver and kidney biopsies.
Haematoxylin and Eosin
For routine examination, haematoxylin and eosin (H&E) is the stain of choice. This stain produces colours different tissue structures, which would otherwise be transparent, so that you can get a detailed view of the tissue.

Gene of the month

The MET receptor tyrosine kinase and its ligand hepatocyte growth factor/scatter factor (HGF/SF) are potential therapeutic targets in many human malignancies, making this pathway an important focus of molecular and cancer research. MET mutations have been detected in various tumours. In addition, many tumour types demonstrate MET and HGF/SF overexpression and amplification.

The MET signal transduction cascade is complex, and manifests in a broad spectrum of mitogenic and morphogenic functions, affecting cell proliferation, migration, differentiation, morphology and survival. Cancer cells commandeer the physiological functions of this signalling axis to facilitate invasion and metastasis. Significant progress has been made in the development of agents that inhibit MET-HGF/SF signalling. In this article, we outline the key features of the MET gene, its protein product and the ligand HGF/SF, to provide an overview of this important signalling pathway and offer a summary of the relevant pathological and clinical directions of research. (read more here)